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This section is more for the unique Transformers series; most generally have a vehicular alternate mode so…
Mutant Techno-organic cars.
2K12 Ninja Turtle's Mutagen apparently affects normal cars. See Speed Demon.
Knight Rider's K.I.T.T. & K.A.R.R. ~Example
Vampire Cars. In other words cars that run on (preferably human) blood. FrightFest's Road Kill's semi-truck would go here too.
NOT AI, driverless.
Best Example: Christine, the 1958 Plymouth Fury